medical ppt Pathology
Atherosclerosis is characterized by intimal lesions called atheromas (also called atheromatous or atherosclerotic plaques), that protrude into vascular lumina. An atheromatous plaque consists of a raised lesion with a soft, yellow, grumous core of lipid (mainly cholesterol and cholesterol esters) covered by a firm, white fibrous cap . Besides obstructing blood flow, atherosclerotic plaques weaken the underlying media and can themselves rupture, causing acute catastrophic vessel thrombosis. Atherosclerosis overwhelmingly causes more morbidity and mortality (roughly half of all deaths) in the Western world than any other disorder. Because coronary artery disease is an important manifestation of the disease, epidemiologic data related to atherosclerosis mortality typically reflect deaths caused by ischemic heart disease (IHD) ; indeed, myocardial infarction is responsible for almost a quarter of all deaths in the United States. Not to be minimized, carotid atherosclerotic disease and stroke are also associated with significant morbidity and mortality .
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