medical ppt Ophthalmology
BACTERIAL CORNEAL ULCER
Being the most anterior part of eyeball, the cornea is exposed to atmosphere and hence prone to get infected easily. At the same time cornea is protected from the day-to-day minor infections by the normal defence mechanisms present in tears in the form of lysozyme, betalysin, and other protective proteins.
infective corneal ulcer may develop when:
either the local ocular defence mechanism is jeopardised,
there is some local ocular predisposing disease, or host’s immunity is compromised, or the causative organism is very virulent.
Pathogenesis and pathology of corneal ulcer
Once the damaged corneal epithelium is invaded by the offending agents the sequence of pathological changes which occur during development of corneal ulcer can be described under four stages, viz., infiltration, active ulceration, regression and cicatrization. The terminal course of corneal ulcer depends upon the virulence of infecting agent, host defence mechanism and the treatment received.
Depending upon the prevalent circumstances the course of corneal ulcer may take one of the three forms:
(A) Ulcer may become localised and heal;
(B) Penetrate deep leading to corneal perforation;
(C) Spread fast in the whole cornea as sloughing corneal ulcer.
Etiology of Infectious Corneal Ulcers and Bacterial Susceptibility.
Amniotic Membrane Transplantation in Peripheral Ulcerative
Peripheral corneal thinning and ulceration
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