Heart rupture (HR) is a major lethal complication of acutemyocardial
infarction (MI), with an incidence as high as 6% in the pre-reperfusion
era,1–4 accounting for up to 30% of hospital mortality. Widespread
availability of reperfusion therapies quickly improved outcomes of
patientswith acuteMI, with a dramatic decrease in mortality, mechanical
complications in general, and HR.3,5–8 Modern therapies focus on
reperfusion strategies and systematic use of medications, but the contemporary
prevalence ofHRcomplications afterMI is notwell known.
Most publications focus on HR after transmural MI, with little or no
information available for this complication in other types of acute coronary
The objective of this study was to determine the incidence of,
and factors associated with, HR in patients with ACS enrolled in
the Global Registry of Acute Coronary Events (GRACE).
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