Medical Powerpoints
medical ppt Ophthalmology
RETINOBLASTOMA
It is a common congenital malignant tumour arising
from the neurosensory retina in one or both eyes.
Incidence
1. It is the most common intraocular tumour of childhood occurring 1 in 20,000 live births.
2. Age. Though congenital, it is not recognised at birth, and is usually seen between 1 and 2 years of age.
3. Sex. There is no sex predisposition.
4. Race. It is rarer in Negroes than Whites.
5. Bilaterality. In 25-30 percent cases, there is bilateral involvement, although one eye is affected more extensively and earlier than the other.
Genetics and heredity
Retinoblastoma (RB) gene has been identified as 14 band on the long-arm of chromosome 13 (13q 14) and is a ‘cancer suppressor’ or ‘antioncogenic’ gene. Deletion or inactivation of this protective gene by two mutations (Knudson’s two hit hypothesis) results in occurrence of retinoblastoma. Retinoblastoma may arise as hereditary and nonherditary forms.
Powerpoint Downloads
Retinoblastoma 1
Retinoblastoma 2
Retinoblastoma – Mapping Genetic Mutations
A Brief Review of Retinal Tumors
Retinoblastoma the paradigm for a genetically inherited cancer
Hepatoblastoma Retinoblastoma – HEPATOBLASTOMA