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What is sarcoidosis ?
Inflamatory disease with non-caseating granulomas.
Sarcoidosis characteristically involves two or more organs
Lung is the most common organ to be affected.
Atypical mycobacteria/ TB -(MkatG-Mycobacterium tuberculosis catalase peroxidase)
Host response to multiple antigens
Genetic susceptibility – key factor
Granuloma – Hallmark
Initial T-helper cell influx
HLA-DRB1*1101 – Higher Risk
HLA-DQB1&0201 – Lofgrens Syndrome
Signs and Symptoms of sarcoidosis are due to involvement of:
Lung,Liver,Eye,Liver,bone marrow, Spleen,calcium metabolism,renal disease,nervous system,cardiac,musculoskeletal system, breast, testes, ovary or stomach.
Galluim 67 scan
Serum ACE levels
Diagnosis of Sarcoidosis:
Compatible clinical features and pathological findings
panda sign-increased activity on parotids and lacrimal glands
lambda sign-increased activity in left paratracheal and left hilar area.
Kveim-Siltzbach procedure:Specific diagnostic test.
An intradermal injection of specificaly prepared tissue derived from the spleen of known sarcoidosis patient is biopsied 4-6 weeks after injection.
Non-caseating granuloma on biopsy highly speciffic for sarcoidosis.
No commercially available kveim Siltzback reagent.
Diagnosis of sarcoiosis can never be certain.(from harrison)
Biopsy Findings on lesion(pathology)
non-caseating granuloma with
-langhans or foreign body type giant cells,
-laminated concretions of calcium
-Schaumann bodies- protein collections
Sarcoidosis Treatment Agents:
Sarcoidosis Powerpoint Downloads
Introduction to Sarcoidosis
Sarcoidosis and Hodgkin’s Disease
Systemic Disease and the Eye- Ocular Sarcoidosis
Interstitial lung Disease(ILD)- Sarcoidosis of lung
Hypercalcaemia and acute renal failure in Sarcoidosis
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