No drug has sparked as much controversy as thalidomide. Originally introduced as a sedative, it was withdrawn from market due to post marketing surveillance reports indicating teratogenicity.
The drug was re-introduced worldwide for a variety of clinical conditions. Thalidomide inhibits angiogenesis and and has anti-inflamatory and immuno modulatory effects.
Thalidomide inhibits TNF-alpha, reduces phagocytosis by neutrophils, increaes production of IL-10 alters adhesion molecule expression, and enhances cell mediated immunity via interaction with T cells.
Thalidomide is used in combination with dexamethasone with good response in Multiple Myeloma.
Thalidomide is also used for Erythema Nodosum Leprosum. If is also used in some cases of lupus Erythematosus.
Adverse Effects of Thalidomide:
Deep Vein Thrombosis
Thalidomide and It’s Derivatives:
Immunomodulatory derivatives of thalidomide are termed IMiDs.Some derivatives are more potent than thalidomide but with fewer side effects. Lenalidomide is one such IMiD with potency similar to Thalidomide but lesser teratogenicity
Selective cytokine inhibitory analogs of Thalidomide are termed SelCIDs. SelCIDs are potent PDE type 4 inhibitors but with no T-cell co stimulatory activity.
Thalidomide Powerpoint Presentations:
New Uses Of An Old Drug – Thalidomide
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