medical ppt Pathology
Thrombocytopenia is characterized by spontaneous bleeding, a prolonged bleeding time, and a normal PT and PTT. A platelet count of 100,000 cells/?L or less is generally considered to constitute thrombocytopenia. Platelet counts in the range of 20,000 to 50,000 cells/?L are associated with an increased risk of post-traumatic bleeding, and spontaneous bleeding becomes evident when counts fall below 20,000 cells/?L. Most bleeding tends to occur from small, superficial blood vessels and produces petechiae or large ecchymoses in the skin, the mucous membranes of the gastrointestinal and urinary tracts, and other sites. Larger hemorrhages into the central nervous system are a major hazard in patients with markedly depressed platelet counts.
Clinically important thrombocytopenias are confined to those disorders in which there is reduced production or increased destruction of platelets. In most cases in which the cause is accelerated destruction, the bone marrow reveals a compensatory increase in the number of megakaryocytes. Hence, bone marrow examination can help to distinguish the two major categories of thrombocytopenia. It is also worth emphasizing that thrombocytopenia is one of the most common hematologic manifestations of AIDS.
Thrombocytopenia: A Brief Overview
Thrombocytopenia – Platelets
Mechanisms of Thrombocytopenia
Neonatal Alloimmune Thrombocytopenia
Thrombocytopenia in the NICU
Anemia, Thrombocytopenia, & Blood Transfusions
Heparin Induced Thrombocytopenia
Management of Heparin Induced Thrombocytopenia
Immune Thrombocytopenic Purpura
Hemostatic System – general information
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